Just as Spiderman is settling into the Marvel Cinematic Universe, Insomniac Games is taking Spidey out on a new trip in a different continuity (comic book characters are like Schrodinger's Cat - they both exist and don't exist... in multiple places). Taking place after Spider-Man has been on the job for a few years, you get to do an adventure in this new take by Insomniac.
Here's a bit on Marvel's Spider-Man from the store page:
Be Spider-Man After eight years behind the mask, Peter Parker is a crime-fighting master. Feel the full power of a more experienced Spider-Man with improvisational combat, dynamic acrobatics, fluid urban traversal, and environmental interactions. A rookie no longer, this is the most masterful Spider-Man you’ve ever played.
Worlds Collide The worlds of Peter Parker and Spider-Man collide in an original action-packed story. In this new Spider-Man universe, iconic characters from Peter and Spider-Man’s lives have been reimagined, placing familiar characters in unique roles.
Marvel’s New York is Your Playground The Big Apple comes to life as Insomniac’s most expansive and interactive world yet. Swing through vibrant neighborhoods and catch breathtaking views of iconic Marvel and Manhattan landmarks. Use the environment to defeat villains with epic takedowns in true blockbuster action.