La-Mulana 2 is, shockingly, the sequel to the acclaimed title La-Mulana that was crowdfunded in 2014. Since La-Mulana was remade for Wii Ware and PC in 2011 (2013 release on Steam), many folks commented that they would like to be able to play it without memories. Rather than work on developing a targeted amnesia device, the developers opted to work on creating a sequel that was made up of many of the same core principles as the first game.
Here's a bit about La-Mulana 2 from their store page:
La-Mulana 2 features sprawling ancient ruins, mind-boggling mysteries, untold numbers of items, and terrible enemies combining to form what is possibly the perfect Metroidvania-style "archaeological ruin exploration action game".
In La-Mulana 2, you take on the role of Lumisa Kosugi - daughter of the previous title’s hero - as she explores the ancient ruins of La-Mulana, said to be the cradle of human civilization. Desperate to find the cause of the numerous recent appearances of monsters from the ruins, Lumisa heads to the "other" La-Mulana: the ruins known as Eg-Lana.
Explore the vast ruins comprising multiple field maps, solve mysteries and riddles using the stone tablets and messages you discover along the way, and take out huge monsters known as "Guardians" as you make your way to the deepest depths of the ruins.
You won’t believe the awesome mystery of Eg-Lana awaiting you at the end of your journey...